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This medication is commonly prescribed by doctors for the following conditions: Various peripheral neuropathies that can be influenced by the three vitamins, including: polyneuropathy, neuralgia, sciatica, lumbago (lower back pain), shoulder-arm syndrome, intercostal neuralgia, trigeminal neuralgia, numbness in the extremities,

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The term 'synergy' gets used when two compounds produce slightly better results together than alonebut true synergy means the combined effect exceeds the sum of individual effects, and that requires targeting rate-limiting steps in a shared pathway