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14-16 For patients receiving either a GLP-1 RA or an SGLT2 inhibitor for CV risk reduction, the ADA recommends considering the addition of the other class if benefits outweigh risks (e.g., if already on a GLP-1 RA, add an SGLT2 inhibitor with proven CV benefit or vice versa) in addition to optimizing other guideline-directed medical therapies for prevention ( Figure 4 )

Semaglutide helps with long-term results, by supporting sustained weight loss over longer periods of time when combined with a healthy diet and regular physical activity

It does not remove the need to eat well, it does not work identically for everyone, and it should not be used to chase complete appetite shutdown

Sections were incubated with 5% normal rat serum followed by further incubation