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Some metal ions have been demonstrated to participate in the formation of proteins and cofactors related to mitochondrial function, and mitochondria themselves are storage centers for various metal ions in cell, which makes a close relationship between mitochondria and metal ions: the normal function of mitochondria depends on sufficient metal ion supply, and the abnormality of mitochondrial structure and function will lead to the abnormality of metal ion level and distribution [13]

In parallel, experimental models of Parkinson disease using dronabinol suggest that cannabinoid receptor activation may attenuate motor impairment and exert neuroprotective effects on dopaminergic neurons (Fagan and Campbell, 2014)