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GLP-1 ONLY How They Work Both medications belong to the incretin class, but Zepbound targets two hormone receptors while Ozempic targets only one: Zepbound: Dual GIP/GLP-1 Receptor Agonist Tirzepatide activates both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptors: GLP-1 effects: Slows gastric emptying, reduces appetite, improves insulin secretion GIP effects: Enhances fat metabolism, amplifies insulin response, may improve satiety through different brain pathways This dual mechanism is believed to explain why Zepbound produces greater weight loss than GLP-1-only medications