The publication was co-financed by the state budget under the program of the Minister of Education, and Science called Science for the Society II, project number NdS-II/SN/0270/2023/01, amount of funding 56,952 PLN total value of the project 1,956,000 PLN
Currently, its FDA-approved only for treating methemoglobinemia, although doctors also use it off-label for other conditions
Retatrutide creates substantial caloric deficits through appetite suppression, but the glucagon receptor activation may actually help mitigate this effect by promoting fat oxidation as the primary alternative fuel source
According to the company and consistent with published pre-clinical literature, it has been studied in animal models for pre-clinical signals related to the gastrointestinal environment, inflammatory responses in the GI tract, and tissue-related processes in tendon and joint contexts - all per pre-clinical animal data, not established human clinical outcomes