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Selectively addressing mitochondrial glutathione and thioredoxin redox systems

plantarum -pMG36e-GLP-1, a genetically engineered Lactobacillus strain that has been combined with GLP-1, has been shown in studies to relieve diabetes symptoms, modulate the intestinal microbiota, and reduce the inflammatory reaction in the pancreatic tissue, suggesting this engineered bacterial strain could provide a promising solution for type 2 diabetes [10]

Indeed, both TNF- and IL-1 can stimulate ROS production and inhibit mitochondrial respiration, whilst increasing glycolytic activity and lactate production (199)