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355,357,358,359 Dysfunction of the BBB includes disruption of BBB integrity (or BBB leakage), changes in BBB transport functions, reduced cerebral blood flow, and neuroinflammation

Brain and Neurodegeneration In neurobiology, glutathione is examined for its impact on brain aging and neurodegenerative mechanisms: Ferroptosis: Glutathione is a key determinant in iron-dependent cell death (ferroptosis), a pathway implicated in certain neurodegenerative conditions

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In addition to its effects on the microbiome, berberine has been shown to increase glucagon-like peptide-1 (GLP-1), a hormone secreted in the small intestine and colon by cells known as L-cells