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They're highly susceptible to heat, light, moisture, and bacterial contamination

859 Compared to healthy individuals, the level of iron in synovial fluid of OA patients is significantly higher and positively correlated with the severity of OA

Clinical Neuropharmacology, 16 (6), 540-549

This suggestion was further insisted as a potential mechanism of TB-500 by the authors of the research study, who also commented that transfection of anti-miR-146a nucleotides reversed the inhibitory effect of T4 on IRAK1 and TRAF6