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Substantial weight reduction can reduce intra-abdominal pressure, improve mobility, and lessen the venous and lymphatic load that produces dependent lower-limb swelling and it improves several of the conditions that cause edema in the first place, including obstructive sleep apnea, hypertension and heart failure with preserved ejection fraction

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The probiotic bacteria Akkermansia muciniphila has also gained attention for its potential to enhance metabolic function, partly by stimulating the production of GLP-1