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The rate of major bleeding on apixaban in real-world registries ranges from 1.5% to 3.5% per patient-year, depending on patient age, renal function, and concomitant medications [15]

El-Sayed IY, Daher A, Destouches D, et al

Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy