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Clinical studies of GHK-Cu combined with 15% L-ascorbic acid demonstrate additive improvements in photoaging parameters, with combination formulations producing 35-45% greater wrinkle reductions than either agent alone

In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

In support of its pro-longevity profile, researchers have noted that higher MOTS-c levels correlate with healthier aging markers in both animals and humans, implying that maintaining MOTS-c might benefit aging tissues

Di Cairano ES, Davalli AM, Perego L, et al