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A periadnexal and perivascular infiltrate with significant loss of pilo-sebaceous units and follicular plugging was also noted (Figures 2A, 2B)

This research is ongoing and is not currently relevant to standard dosing, but it underscores the principle that more drug means more side effects

Individuals with Riehl melanosis have been observed to have certain genetic changes, including a higher activity of an enzyme called guanine deaminase

However, OCA has several drawbacks, such as elevated LDL levels, itching, and high cost [65]