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Gao C, Li B, He Y, Huang P, Du J, He G, et al

In contrast, the following features indicate pain sources outside the bladder and a higher risk of failure: Large capacity under anesthesia Absence of Hunner lesions, Lack of relief with local anesthetic bladder instillations, Pelvic muscle tightness/tenderness, Genital hyperesthesia, Pain beyond the pelvis, such as the presence of widespread pain, and, most important, Polysymptomatic or polysyndromic presentation

People who are blind or have vision problems should not use the Pen without help from a person trained to use the Pen