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SU = sulfonylurea a Ontario prices presented Source: Sponsors pharmacoeconomic submission 1 Results of the sponsors base case suggested an incremental cost of $3,355,258 in Year 1, $10,231,784 in Year 2, and $21,706,463 in Year 3, for a total incremental cost of $35,293,505 over the 3-year time horizon, when oral semaglutide is reimbursed as an adjunct to diet and exercise to improve glycemic control in adults with T2DM as monotherapy when metformin is considered inappropriate due to intolerance or contraindications or in combination with other medicinal products

Figure 3: Changes in fEPSP slope from baseline in response to different inhibitory compounds

Avoid application to broken or irritated skin, and discontinue if significant irritation develops

Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme found in every cell of your body, playing a vital role in energy production, cellular repair, and healthy aging