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While recent breakthroughs have demonstrated the clinical potential of biologics, several critical challenges must be addressed before their full therapeutic potential can be realized

Infiltration of M1-type macrophages into visceral fat leads to chronic release of pro-inflammatory cytokines, such as IL-1, which drive ovarian interstitial fibrosis and hemodynamic changes (62, 63)

Clinical studies and reported cases suggest that chest pain is not a common side effect of semaglutide, but it can happen

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