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Once they are significantly diminished, a prolonged deficiency can lead to substantial damage, especially to the nervous system

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Therefore, in-depth analysis of the exact regulatory network of Bacteroidetes in the pathogenesis of OA through the gut-joint axis, and clarification of the functional specificity of different Bacteroides strains and their interactions with host metabolism, immune and inflammatory pathways, are of great theoretical and clinical significance for accurately understanding the mechanism of the influence of gut microbiota on OA and developing probiotic intervention strategies targeting specific strains

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