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These modifications significantly reduce IGF-1 LR3's binding to IGF binding proteins while maintaining high affinity for the IGF-1 receptor, making it a powerful research tool for studying cell proliferation, differentiation, and survival signalling pathways

HepG2 ATP7B-KO cells have been generated by nucleofection of a custom-made CompoZr zinc finger nuclease plasmid (Sigma

These models demonstrate that rats treated with SFN exhibit increased sniffing times and greater engagement with unfamiliar rats during social tests, suggesting an improvement in social cognition and interaction