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In addition to glucuronidation that is responsible for metabolism of approximately 55% of paracetamol as the major metabolic pathway, approximately 30% of circulating paracetamol may be also conjugated by sulfotransferase, as shown in Fig

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Microbial Dysbiosis Modulates Protein Clearance Mechanisms, Autoimmune Functions, and Central Nervous System Immune Recruitment Aggregated misfolded protein and autophagolysosomal-proteasomal pathways participate in a vicious cycle that causes cytotoxicity and exacerbates hallmark pathologies of neurodegenerative disorders (Monaco and Fraldi, 2020)