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174 Conversely, excessive autophagy can result in the erroneous engulfment of essential proteins or normal organelles such as mitochondria

Indeed, several landmark clinical trials, such as the Scandinavian Simvastatin Survival Study (4S) (4), Cholesterol and Recurrent Events (CARE) (5), Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) (6), West of Scotland Coronary Prevention Study (WOSCOPS) (7), Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS) (8), Heart Protection Study (HPS) (9), and the Anglo-Scandinavian Cardiac Outcome Trial Lipid-lowering Arm (ASCOT-LLA) (10), have demonstrated the benefit of lipid lowering with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors or statins for the primary and secondary prevention of CHD