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Timothy Garvey, MD, FACE Professor of Medicine University of Alabama at Birmingham Disclosures: Garvey reports conducting clinical trials funded by his institution for Eli Lilly, Epitomee, Novo Nordisk and Pfizer and serving as a volunteer on advisory board without receipt of financial compensation for Eli Lilly, Novo Nordisk, JAZZ Pharmaceuticals and Boehringer Ingelheim

It is a tetrameric enzyme consisting of four identical tetrahedrally arranged subunits of 60 kDa, which contains a single ferriprotoporphyrin group per subunit and has a molecular mass of about 240 kDa 2.1.3

These findings demonstrate that IMP-366 increases susceptibility to erastin-induced ferroptosis

While originally approved to help manage type 2 diabetes, it is also prescribed off-label by healthcare providers as part of medical weight loss programs