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On chromosome 1, we observed a significant number of associated variants near the TMCO1 gene, which has been implicated in various disorders, including POAG, craniofacial dysmorphism, skeletal anomalies, and impaired intellectual development syndrome 25

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doi: 10.1016/S0928-4257(00)00147-9

With all this in mind, it is expected that Frag 176-191 may also have depot-specific preferences on adipocytes