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Cognitive effects of low-dose topiramate compared with oxcarbazepine in epilepsy patients

[20] Through its role as an HDAC inhibitor, butyrate influences the expression of genes involved in: [27] Mitochondrial function - enhancing cellular energy production Synaptic plasticity - supporting learning and memory formation Neuronal protection - increasing antioxidant defenses Neurogenesis - potentially supporting the formation of new neurons Animal studies have shown that butyrate supplementation is associated with improvements in memory performance and learning ability in preclinical models, especially those simulating aging

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However, this change was not conserved in female WT or GLPDRKO mice (Supplementary Fig