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The hydrodynamic radius (Rh) and polydispersity index (Pd%) were calculated using DynaMax v1.0 analysis software (Beckman Coulter, USA), following the manufacturers guidelines

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There was also a slight increase in the number of foot and toe amputations during the CANVAS trial than is usual so further studies are needed to assess if this is a problem and who is more at risk

Never place your semaglutide vial in the freezer, even briefly, as freezing can permanently damage the compound's molecular structure and render it ineffective or potentially unsafe for injection