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Early signs include tingling or 'pins and needles' in the feet and hands, numbness in the extremities, burning pain (often worse at night), balance problems, and muscle weakness

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Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation (Conesa et al., 2023)

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