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For mild localised injection site reactions: Cold compress application apply a clean, cool (not ice-cold) compress to the affected area for 1015 minutes to reduce inflammation and discomfort Avoid rubbing or scratching the injection site, as this may exacerbate irritation Topical emollients regular application of fragrance-free moisturisers can soothe dry or irritated skin Oral antihistamines non-sedating antihistamines such as cetirizine or loratadine may help relieve itching if troublesome For more significant or generalised rashes: Topical corticosteroids mild-to-moderate potency topical steroids may be prescribed for inflammatory rashes

The binding affinity of GHK for copper(II) is extremely high in the picomolar range for the apparent dissociation constant at physiological pH which means that in the presence of physiological copper, free GHK and copper-bound GHK readily interconvert with the bound form dominating