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Researchers have suggested that this distinction is significant: exogenous growth hormone can overwhelm normal feedback loops, whereas tesamorelin more closely restores a youthful hormonal secretion rhythm, which may help explain why its effects are relatively selective for visceral fat rather than producing large shifts in total body weight

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GH leaves the systemic circulation and crosses the blood-brain barrier (BBB) reaching its responsive sites in the brain, including the choroid plexus, hypothalamus, and hippocampus