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MHRA-licensed options available in the UK include orlistat (Xenical or Alli), semaglutide (Wegovy), and liraglutide (Saxenda), all recommended by NICE under specific clinical criteria and used alongside dietary and lifestyle changes

A 2024 commentary in Lancet Diabetes & Endocrinology reported that GLP-1 users can lose anywhere from 25 to 39% of their muscle mass over a 9-to-18-month period, which is a rate of decline several times greater than normal age-related muscle loss

Lowering visceral fat Deep belly fat actively releases inflammatory signals throughout your body