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Pyridostigmine therapy for Myasthenia Gravis

The complexity of DPP4 action stems from (i) a long list of substrates cleaved by the enzyme including hormones, growth factors, and cytokines, (ii) an additional function of this protein being a binding partner at the surface of different cells, specifically immune cells, and (iii) the recent discovery that DPP4 is an adipokine with different endocrine functions

These agents have been supported by important clinical trials, including Satiety and Clinical Adipose Liraglutide Evidence (SCALE), Semaglutide Treatment Effect in People with Obesity (STEP) program trials, and Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) (44)

Additionally, the hydrolysis of ester linkages degrades PLGA into its monomers (glycolic and lactic acid), which could be metabolized and eliminated by the body, reflecting its biocompatibility 97