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Nevertheless, 10 years after the diagnosis of T2DM, low-level albuminuria is present in 24.9% of the patients and 5.3% already present macroalbuminuria ( Glomerular Insulin Actions Podocytes are the primary constituent cell of the glomerulus, with their long finger-like projections to the glomerular capillaries at the glomerular basement membrane (GBM)

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The upregulation of NRF2 and SOD1, along with the activation of ROS scavenging pathways, can lead to resistance to chemotherapy or targeted therapy in various tumors