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Previous biochemical and structural studies have established that there are at least two distinct c-MET binding sites on HGF 13

Although not evaluated here, lower intracellular GSH levels would also deactivate the GSH-dependent GPX4, further enhancing ferroptotic cell death (8, 38)

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Differentially expressed genes (DEGs) between OA and normal cartilage tissues in the GSE98918 dataset were identified using the limma package 21 , with the significance threshold set at |logFC| 0.5 and adjusted p -value 0.8 indicates good diagnostic performance 24