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Ultrastructural pathology and restoration in PFC and hippocampal CA1 neurons Transmission electron microscopy (TEM) analysis of prefrontal cortex (PFC) and hippocampal CA1 neurons revealed significant ultrastructural alterations across experimental groups

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Challenging rats with MTX evoked hepatotoxicity as manifested by elevated liver function enzymes in serum and disarrayed hepatic histopathologic features, which aligns with previous reports (Karabulut et al., 2020

These findings underscore the need to devise strategies to eradicate intracellular persisters, especially given the limited antibiotic options available for intracellular infections