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Additionally, a U.S

24 Since HACE is rarely reported, systematic analysis of its risk factors is still lacking

Specifically, GLP-1 receptor activation stimulates the production of cAMP, thereby promoting glucose-dependent insulin secretion by pancreatic -cells, inhibiting glucagon secretion by -cells, delaying gastric emptying, and suppressing the hypothalamic appetite center, resulting in glucose-lowering and weight-loss effects (Nauck et al., 2021

The estimated global market of polyphenols in 2018 was 1.28 billion US dollars, with a perspective increase expressed as compounded average growth rate (CAGR) of more than 7.2% from 2019 to 2025 (Abbasi-Parizad et al