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It reduces oxidative stress, which happens when theres an imbalance between free radicals and the bodys antioxidant defenses

IGF-1 can activate matrix metalloproteinases through both AKT and MAPK pathways subsequently activating TGF1 leading to nuclear translocation of -catenin and EMT [112]

10.1016/bs.ircmb.2021.02.006 Int

Following this, we employed a stimulation regimen of 1 min ON and 5 min OFF to assess mechanical and thermal sensitivity