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The clinical evidence supporting semaglutide is extensive: randomized controlled trials show sustained weight loss, improved blood sugar control in people with prediabetes, and cardiovascular benefits in patients with type 2 diabetes

Correlative data also demonstrates a relationship between COPD, notch signaling, muc5AC mRNA, and pulmonary neuroendocrine cells (which synthesize CGRP among many other neuropeptides) [159]

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Wegovy slows gastric emptying (an effect that diminishes over time), increases feelings of fullness, and reduces appetite, leading to decreased caloric intake and subsequent weight loss