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Further investigation into how noradrenergic degeneration interacts with AD pathology and contributes to cognitive decline, may help explain why some LLD are at heightened risk for dementia and may identify those most likely to benefit from noradrenergic-targeted treatments

More recent studies using VMAT2 and DA transporter radiotracers, which are more sensitive to early abnormalities than 18 F-DOPA PET, have estimated the initial decline in dopaminergic pre-synaptic activity to be up to 17 years before diagnosis

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Unlike other antioxidants that work in specific tissues or target particular free radicals, glutathione functions as a comprehensive cellular protection system