Therefore, in order to transform intestinal fungi from promising biomarkers into reliable diagnostic and therapeutic targets, it is recommended that large-scale, multi-center, prospective longitudinal cohort studies be conducted in the future
Several known Nrf2 natural activators (e.g., curcumin, sulforaphane, resveratrol, and naringenin) played an important role in regulating Nrf2 mechanisms ( in vitro studies, animal studies, and clinical studies, aiming to elucidate molecular mechanisms related to the etiology of ASD and to open up a new approach to prevent and/or treat ASD
Moreover, biological markers indicated that SFN enhances cellular defenses against inflammation and oxidative stressfactors linked to ASD
Protective immunity was obtained by transfer of immune, H