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Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris: A randomized open-labeled study

6a and 7f)

Research has consistently documented that NAD+ levels decrease progressively with age in various tissues, with studies showing 50-80% reductions in NAD+ concentrations in aged animals compared to young controls

Its a way to support your bodys natural hormonal rhythm rather than replacing hormones directly