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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

Impact of Semaglutide on Heavy Drinking Over 26 Weeks Researchers assigned participants to receive a once-weekly 2.4 mg dose of semaglutide or placebo for 26 weeks

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Rather than serving as a first-line treatment, it is typically considered an adjunctive therapy that may complement more established approaches, such as physical therapy, exercise modification, and other evidence-based interventions