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Heterogeneities were assessed within and between study designs for America (I 2 = 55.4%, p = 0.106), Asia (I 2 = 75.0%, p = 0.007), and overall (I 2 = 69.5%, p = 0.002) (Fig

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NAPQI is highly reactive and rapidly conjugates with critical cellular enzymes, interfering with normal cellular function and destabilizing the mitochondrial membrane 5