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In some cases, this leads to therapeutic compromises, where treatment decisions are shaped by access rather than optimal efficacy

They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial

It consists of eight pivotal trials running in parallel, enrolling more than 5,800 participants in total across the weight-management and diabetes indications, plus a separate roughly 10,000-patient cardiovascular outcomes trial

Preliminary data suggest that -Hydroxy--methylbutyrate may attenuate lean mass loss during caloric restriction [54]