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20 In the same year, Thakkar and Billa also compared the benefits of the different forms, and argued that methyl-B12 alone may not address the neurological complications in B12 deficiency that arise partly from the lack of adenosyl-B12

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Blocks the NNMT enzyme that converts nicotinamide to N-methylnicotinamide, preserving nicotinamide for NAD+ synthesis and cellular energy pathways

Other Uses: Often used in cycling longevity protocols or seasonal reset phases to support cellular repair, circadian alignment, and healthy aging rather than continuous daily use