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the definition of this profile showed a good level of homogeneity (mean inter-item Spearman 0.25) [41] and has been extensively described previously as belonging to the immuno-metabolic depression (IMD) domain, based on previous findings on individual symptoms with immuno-metabolic dysregulation [2]

Subsequently, the full texts of the included studies were analyzed by both researchers independently, ensuring impartiality and consistency

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In current study, T-RDN by itself caused significantly greater urine flow, sodium excretion and increased CrCl at baseline in both HF and Sham