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Acknowledgements This work was supported by the grant from the Natural Science Foundation of China (82401786), Natural Science Foundation of Zhejiang Province (LQ24C090002), Qiushi Youth Program from Scientific Research Cultivation Foundation (J-202406), Hangzhou Science and Technology Bureau, Zhejiang Provincial Medical and Health Technology Project (2024KY246), China National Students Research Training Program (202313021031), and the Key Research Project of Joint Institute of Tobacco and Health to MDL (2021JC06)