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Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment directly influencing tumor cell growth, angiogenesis, and immune suppression

doi: 10.1128/AAC.47.1.170 32 SchirmerR

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Instead, regarding atypical Spitz tumor, it is acknowledged that there is the need of a risk stratification (46), evidently because neoplasms belonging to the Spitz lineage distribute along a spectrum of increasing histopathological atypia, with their malignant end being Spitz melanoma (14, 15)