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The findings were disappointing: Only one study showed significant lightening, and that was limited to sun-exposed areas like the face and forearms One study found that 37.5% of subjects experienced temporary improvements, but within six months after stopping treatment, only 6.2% maintained lighter skin The effects were inconsistent across different body parts and age groups Researchers concluded that glutathione is not effective enough as a skin-whitening agent because effects were limited and unsustainable What Is Vitamin C and How Does It Brighten Skin

C., Uckert, S., Stief, C

Vitamin E acts primarily on lipid layers, stabilizing cell membrane structures and avoiding lipid peroxidation damage

Most patients begin at lower doses and progress upward over weeks or months as their tolerance improves