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Semaglutide and tirzepatide studies show roughly two-thirds of lost weight returning within a year, with most regain in the first months and about one-third to 40% of the loss still held at one year. Retatrutide may produce greater regain pressure because its glucagon support for resting metabolism fades while appetite returns

But these high doses are necessary to help treat people with a deficiency

Understanding any negative effects of current practice and how GPs can better meet the needs of this marginalised group is key to improving safety and care, they concluded