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Phosphoribosyl pyrophosphate synthetase 1 (PRPS1), the key enzyme of the de novo nucleotide synthesis pathway, is O -GlcNAcylated by O -GlcNAc transferase (OGT), which triggers PRPS1 hexamer formation and relieves nucleotide product-mediated feedback inhibition, thereby boosting PRPS1 activity

Cancer 110 (8), 18681874

In the past 40 years, numerous placebo-controlled trials have examined the effect of vitamin C supplementation on the prevention and treatment of colds

Damage-associated molecular patterns (DAMPs) are of particular interest, as they can trigger the inflammatory response observed in the active stage of vitiligo, with a series of DAMP-associated proteins existing in vitiligo.4 The DAMP with the most evidence of association with vitiligo is heat shock protein 70 (HSP70), which belongs to the family of intracellular chaperones whose function is to prevent incorrect protein folding