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Some people dont produce enough intrinsic factors, and they also can become deficient

Gastric bypass patients, people taking metformin long-term, and those with celiac disease or Crohn's disease may have impaired B12 absorption and genuinely benefit from injected B12 during semaglutide therapy

The largest published trial (METAOD006/OPTIONS) randomized 502 adults with obesity to AOD-9604 or placebo for 24 weeks alongside a diet and exercise program

We appreciate the commenters' insights on these challenges and we agree that the balance between protecting patient privacy and enabling meaningful quality improvement is important