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When exercise was added, these negative effects were largely prevented: exercised rats had higher total bone mineral content, lean mass, and serum IGF-1, and their bone mechanical strength was maintained despite reduced energy availability

C.-S.et al (2021)

Ozempic (for type 2 diabetes, with weight loss often seen as an added benefit) is priced similarly but typically gets better coverage under diabetes formularies

Tirzepatide's labeling specifically advises using a barrier method or switching to a non-oral contraceptive for four weeks after starting and after each dose increase