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doi:10.3390/ijms25158202

Common research applications include in-vitro fibroblast and keratinocyte studies, animal wound-healing models, hair-follicle and dermal-papilla research, post-procedure skin-recovery models, antioxidant-pathway investigations, and gene-expression profiling

Antioxidant Boost The cream often includes antioxidants that combat free radicals, supporting overall skin health

However, taking coffee by mouth may be safer and more effective : blood caffeine levels were 3.5x higher after drinking coffee than after an enema in a trial on 11 people [35+, 36, 37, 38, 39, 40, 41, 42, 43, 44]